Internal Medicine Glossary

A

  • Anorexia

    • Definition: Loss of appetite.

    • Clinical relevance: May indicate systemic illness (e.g., malignancy, chronic infection), GI inflammation, or metabolic disorders.

    • Red flags: Persistent anorexia with weight loss.

  • Achalasia

    • Definition: Esophageal motility disorder causing impaired relaxation of the lower esophageal sphincter.

    • Presentation: Progressive dysphagia to both solids and liquids, regurgitation of undigested food, weight loss.


B

  • Bloating

    • Definition: Sensation of abdominal fullness or distension.

    • Common causes: Irritable bowel syndrome (IBS), small intestinal bacterial overgrowth (SIBO), lactose intolerance, constipation.

    • Clinical tip: Ask about relation to meals, flatulence, or changes in bowel habits.

  • Borborgymi

    • Definition: Audible bowel sounds due to gas movement.

    • Significance: Hyperactive sounds seen in diarrhea, early obstruction; absent sounds may indicate ileus or peritonitis.


C

  • Constipation

    • Definition: Infrequent (<3 per week) or difficult passage of stool.

    • Causes: Functional (diet, inactivity), obstructive lesions, medications, metabolic diseases (hypothyroidism).

    • Associated symptoms: Straining, hard stools, sensation of incomplete evacuation.

  • Chronic Diarrhea

    • Definition: Diarrhea lasting >4 weeks.

    • Causes: Inflammatory bowel disease, malabsorption syndromes (celiac disease), infections (e.g., Giardia), medications.

  • Colic

    • Definition: Intermittent, cramping abdominal pain.

    • Examples: Biliary colic (gallstones), renal colic, intestinal obstruction.


D

  • Dysphagia

    • Definition: Difficulty swallowing; categorized as oropharyngeal (difficulty initiating swallow) or esophageal (sensation of food sticking).

    • Causes: Neurological disorders (stroke), structural lesions (esophageal cancer), motility disorders (achalasia).

  • Dyspepsia

    • Definition: Upper abdominal discomfort or burning sensation, often postprandial.

    • Differential: GERD, peptic ulcer disease, gastritis, functional dyspepsia.

  • Diarrhea

    • Definition: Increased stool frequency and liquidity.

    • Duration: Acute (<2 weeks), chronic (>4 weeks).

    • Red flags: Bloody stools, weight loss, nocturnal symptoms, systemic signs.


E

  • Emesis (Vomiting)

    • Important details: Timing (early morning in pregnancy or increased intracranial pressure), contents (bile, blood), frequency, and triggers.

    • Causes: Gastroenteritis, obstruction, CNS disorders, pregnancy.

  • Early Satiety

    • Definition: Feeling full after eating a small amount.

    • Causes: Gastric outlet obstruction, malignancy, gastroparesis.


F

  • Fecal Incontinence

    • Definition: Loss of voluntary control over defecation.

    • Causes: Anal sphincter injury, neuropathy, diarrhea, spinal cord disease.

  • Fever

    • Significance: May suggest infectious or inflammatory causes such as gastroenteritis, appendicitis, or diverticulitis.


G

  • Gastroesophageal Reflux Disease (GERD)

    • Symptoms: Heartburn, regurgitation, sour taste.

    • Aggravating factors: Meals, lying down, bending forward.

  • Guarding

    • Definition: Involuntary muscle contraction on abdominal palpation.

    • Clinical importance: Sign of peritoneal irritation or acute abdomen.


H

  • Hematochezia

    • Definition: Passage of fresh blood per rectum.

    • Common causes: Hemorrhoids, diverticular bleeding, colorectal cancer.

    • Urgency: Large volumes warrant urgent evaluation.

  • Hematemesis

    • Definition: Vomiting of blood.

    • Causes: Peptic ulcer, varices, Mallory-Weiss tear.

  • Hepatomegaly

    • Clinical clue: Suggests liver pathology, right heart failure, or infiltrative diseases.


I

  • Icterus (Jaundice)

    • Definition: Yellow discoloration due to bilirubin accumulation.

    • History points: Onset, associated pruritus, stool and urine color changes, abdominal pain.

  • Incontinence

    • See fecal incontinence.


L

  • Liver Function Symptoms

    • Fatigue, easy bruising, spider angiomata, ascites — suggest chronic liver disease.

  • Lactose Intolerance

    • Symptoms after dairy ingestion: bloating, diarrhea, flatulence.


M

  • Melena

    • Definition: Black, tarry stools due to digested blood.

    • Cause: Upper GI bleeding (peptic ulcer, varices).

  • Malabsorption

    • Symptoms: Diarrhea, weight loss, steatorrhea, vitamin deficiencies.

    • Causes: Celiac disease, pancreatic insufficiency, small bowel bacterial overgrowth.


N

  • Nausea

    • Common symptom with various GI and systemic causes.


O

  • Odynophagia

    • Painful swallowing; suggests esophageal mucosal inflammation or infection (e.g., candida, herpes).

  • Obstruction

    • Symptoms: Vomiting, abdominal distension, constipation, colicky pain.


P

  • Pain (Abdominal)

    • Characterization: Location, quality (sharp, dull, colicky), timing, radiation, exacerbating/relieving factors.

    • Important: Differentiate visceral, parietal, or referred pain.

  • Pallor

    • Sign of anemia from chronic GI blood loss.

  • Peritonitis

    • Severe abdominal pain with guarding and rigidity, suggesting surgical emergency.


R

  • Rectal Bleeding

    • Requires differentiation from hematochezia; important to clarify source and urgency.

  • Regurgitation

    • Passive return of food or acid; often in GERD or motility disorders.


S

  • Steatorrhea

    • Fatty, foul-smelling stools; hallmark of malabsorption.

  • Strangulation (Bowel)

    • Severe ischemic pain; surgical emergency.

  • Stool Characteristics

    • Color, consistency, presence of mucus, blood — crucial for diagnosis.

  • Syncope

    • May result from hypovolemia due to GI bleeding.


T

  • Tenesmus

    • Urge to defecate despite empty rectum; common in proctitis or IBD.

  • Tenderness

    • Localized pain on palpation indicating inflammation.

  • Trauma

    • Important history in acute abdomen.


V

  • Vomiting

    • See emesis.

  • Vomiting Blood

    • See hematemesis.


W

  • Weight Loss

    • Unintentional, alarming symptom suggesting malignancy, chronic infection, or malabsorption.


Y

  • Yellowing of Skin/Eyes

    • See icterus/jaundice.


Additional History Tips:

  • Chronology and Progression: Always document onset, duration, and progression of symptoms.

  • Associated Symptoms: Fever, night sweats, rash, joint pains may indicate systemic disease.

  • Risk Factors: Alcohol use, NSAID use, travel history, sexual history (for hepatitis), family history of GI diseases.

  • Impact on Daily Life: Weight loss, fatigue, and ability to eat should be explored to assess severity.

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